Xanthine Oxidase Activity in Regenerating Liver* by Muriel Feigelson, Philip Feigelson, and Paul R. Gross
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چکیده
The xanthine oxiclase activity of mouse regenerating liver has been shown to be elevated during the period of rapid liver growth and proliferation. This increase is evident when the enzyme activity is expressed per unit wet tissue weight, per unit nitrogen, or per cell. The adrenal cortex probably plays only a minor role in implementing this phenomenon. Further augmentation of the xanthine oxidase level of regenerating liver is not induced by the administration of large quantities of the substrate, xanthine, to the animal.
منابع مشابه
Xanthine Oxidase Activity in Regenerating Liver
The xanthine oxidase activity of mouse regenerating liver has been shown to be elevated during the period of rapid liver growth and proliferation. This increase is evident when the enzyme activity is expressed per unit wet tissue weight, per unit nitrogen, or per cell. The adrenal cortex probably plays only a minor role in implementing this phenomenon. Further augmentation of the xanthine oxida...
متن کاملThe Inhibition of Xanthine Oxidase in Vitro by Trace Amounts of Z-ascorbic Acid by Philip Feigelson
For many years it has been known that numerous compounds can act as inhibitors of xanthine oxidase in vitro. This has been demonstrated for such diverse substances as cyanide (I), copper (Z), oxidized p-aminophenol (3), pyrogallol (4), 6-pteridylaldehyde (5), Antabuse (6), and numerous flavonoids (7). Few, if any, of the above inhibitors can be considered as being present and normally participa...
متن کاملThe Inhibition of Xanthine Oxidase in Vitro by Trace Amounts of Z-ascorbic Acid by Philip Feigelson
For many years it has been known that numerous compounds can act as inhibitors of xanthine oxidase in vitro. This has been demonstrated for such diverse substances as cyanide (I), copper (Z), oxidized p-aminophenol (3), pyrogallol (4), 6-pteridylaldehyde (5), Antabuse (6), and numerous flavonoids (7). Few, if any, of the above inhibitors can be considered as being present and normally participa...
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Quantitative alterations in the purine catabolic enzyme, xanthine oxidase, have been observed in neoplasia and nonmalignant hyperplasia. A decrease in the xanthine oxidase level per cell during carcinogenesis in both liver and breast tumors has been reported (1, 8). Likewise, Bennett and associates ~ have shown that several experimental tumors are low in xanthine oxidase activity. In contrast, ...
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A recent finding from this laboratory indicated that the incubation in vitro of purified xanthine oxidase with trace amounts of l-ascorbic acid resulted in a marked inhibition of the enzymatic activity (1, 2). Since the physiological mode’of action of Z-ascorbic acid is still obscure, it seemed desirable to determine whether ascorbic acid would, in the intact animal, exert a similar effect on x...
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